In an attempt to identify new genes and molecules in charge for coronary artery disease (CAD), researchers will use state-of-the-art genetic techniques to examine DNA from over 20,000 heart patients. CAD is a order in which plaque (a compound of fat, cholesterol and other substances found in the blood) builds up inside the coronary arteries.
The study, which may help develop new analytical and treatment strategies, is being undertaken by postgraduate researcher Paraskevi Christofidou of the Department of Cardiovascular Sciences at the University of Leicester (UL). Christofidou said: 'Coronary Artery Disease - a disease cause narrowing of arteries in the heart - remains a major cause of death worldwide. Shockingly, in the USA on normal one person dies of this disease every 34 seconds.'
In the UK, it causes over 100,000 deaths a year, approximately one in five deaths in men and one in six deaths in women. 'Various risk factors such as high blood pressure, smoking, obesity and enlarged levels of cholesterol play a significant role in the progression of CAD,' Christofidou said. 'There is also proof that familial predisposition is a strong risk factor. Risk of CAD increases by almost 50 percent if one of your relatives has a history of heart disease,' added Christofidou.
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