German scientists say a drug taken to treat type-2 diabetes may be efficient against Alzheimer’s disease. The researchers said the drug metformin counteracts change of the cell structure protein known as Tau in mice models. These cell structure changes are a important cause of the development of Alzheimer’s, the researchers said in a statement. The scientist were from the German Center for Neurodegenerative Disease, the University of Dundee and the Max Planck-Institute for Molecular Genetics.
During their research, the scientists also said they exposed the molecular mechanism of metformin. “If we can prove that metformin shows also an "effect in humans, it is certainly a good applicant for an efficient therapy on Alzheimer’s disease, Sybille Kraub, from the Center for Neurodegenerative Diseases, said in a report. The researchers said Alzheimer’s disease occur when neurons in the brain die, which lead to cognitive injury. Also, it is characterized by the configuration of Tau protein deposits in nerve cells.
Dr. Anne Corbett, research infrastructure manager for the Alzheimer’s Society, said the study offered some hope of a new and efficient drug treatment for the disease, but further research is needed to understand the link between Alzheimer’s and diabetes. “Previous research has recommended that metformin decrease the risk of dementia in diabetic people, and this study give some understanding of why this might be,” Corbett said in a statement. “'A million more people are set to expand dementia in the next 10 years. It is significant that people maintain a healthy lifestyle in order to decrease their risk and that larger investment in dementia research is made to more our understanding of the condition.”
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During their research, the scientists also said they exposed the molecular mechanism of metformin. “If we can prove that metformin shows also an "effect in humans, it is certainly a good applicant for an efficient therapy on Alzheimer’s disease, Sybille Kraub, from the Center for Neurodegenerative Diseases, said in a report. The researchers said Alzheimer’s disease occur when neurons in the brain die, which lead to cognitive injury. Also, it is characterized by the configuration of Tau protein deposits in nerve cells.
Dr. Anne Corbett, research infrastructure manager for the Alzheimer’s Society, said the study offered some hope of a new and efficient drug treatment for the disease, but further research is needed to understand the link between Alzheimer’s and diabetes. “Previous research has recommended that metformin decrease the risk of dementia in diabetic people, and this study give some understanding of why this might be,” Corbett said in a statement. “'A million more people are set to expand dementia in the next 10 years. It is significant that people maintain a healthy lifestyle in order to decrease their risk and that larger investment in dementia research is made to more our understanding of the condition.”
useful links : transport rankings
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