Autoimmune diseases may underlie wounds that don’t heal

Wounds that are slow to heal or do not at all may have an underlying autoimmune disease, according to a new study the finding represents an difficult link that could lead to important new insights in wound healing, say researchers at Georgetown University Medical Center.

The study was sparked by the keen watching of Georgetown rheumatologist Victoria Shanmugam, M.D., who began noticing something rather curious in her patients with autoimmune diseases any open wound they had was very slow to heal.their recovery was even more protracted than in patients through wounds who have diabetes, a disease that is notoriously damaging to blood vessels and to normal skin repair.

So Shanmugam and her colleagues conducted a chart review of people who sought care at a high-volume wound clinic at Georgetown University Hospital to determine the prevalence of autoimmune diseases the study included patients with open wounds regularly leg ulcers who were treated through a three-month period in 2009 of the 340 patients, 49 percent had diabetes, which she says is a typical rate.

Diabetes linked to celiac disease

About 3 million people in the U.S., about 1 in 133, have diagnosed celiac disease expert contend that lots of more with celiac disease go undiagnosed because they have no symptoms or only general symptoms that sufferers mistakenly quality to any number of other physical conditions.

Symptoms of celiac disease frequently include diarrhea and bloating, but may also include weight loss, migraine, arthritis, chronic skin conditions and depression.

Celiac disease it is an autoimmune disease cause by a reaction to ingesting gluten, which is contained in grains and numerous processed foods the cells in the gut attack gluten and, in the process, damage the gut lining in severe cases, this consequences in poor absorption of many important nutrients.

Type 2 Diabetes possible an Autoimmune Disease

The development of insulin confrontation that leads to type 2 diabetes could be due to an immune system reaction. New research has recognized immune system antibodies among obese people who are insulin-resistant that are not found in people absent insulin resistance. The findings of the study were newly published online in the journal Nature Medicine. According to learn co-author Dr. Daniel Winer, an endocrine pathologist at the University Health Network of the University of Toronto in Ontario, Canada, “We are in the progression of redefining one of the most ordinary diseases in American as an autoimmune disease, rather than a purely metabolic disease.”

He went on to explain, “This work will alter the way people think about obesity, and will likely impact medicine for years to come as physicians begin to switch their focus to immune alter treatments for type 2 diabetes.” Winer, along with his twin brother, Shawn Winer, of the Hospital for Sick Children at the University of Toronto, and Stanford research relate Lei Shen are co-first authors of the study. Winer was a postdoctoral fellow at Stanford University in California while the research began.

Almost 26 million Americans suffer from diabetes, according to the U.S. Centers for Disease Control and Prevention. The vast mass of cases are type 2 diabetes. With type 2 diabetes, the body either does not manufacture enough insulin, or the boy’s cells ignore the insulin. The body needs insulin in order to use glucose for energy. When food is consumed, sugars and starches are broken down into glucose to fuel the body’s cells, and insulin move it from the blood into the cells. A build up of glucose in the blood that is not full to the cells leads to diabetes complications. In Type 1 diabetes, defined as an autoimmune disease, the body fails to create insulin due to destruction of the insulin-producing beta cells in the pancreas by the immune system.

Hashimoto's thyroiditis

Hashimoto's thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease in which the thyroid gland is slowly destroyed by a variety of cell and antibody mediated immune processes. It was the first disease to be known as an autoimmune disease. It was first described by the Japanese expert Dr. Hakaru Hashimoto in Germany in 1912. Symptoms of Hashimoto's thyroiditis include weight gain, depression, mania, sensitivity to warm and cold , paresthesia, fatigue, panic attacks, bradycardia, tachycardia, high cholesterol, hasty hypoglycemia, constipation, migraines, muscle weakness, cramps, memory loss, infertility and hair loss.

The genes concerned vary in different ethnic groups and the incidence is increased in patients with chromosomal disorders, including Turner, Down's, and Klinefelter's syndromes usually linked with autoantibodies against thyroglobulin and thyroperoxidase. The underlying specifics of the immune system destruction of thyroid cells are not clearly understood. Various autoantibodies may be present against thyroid peroxidase, thyroglobulin and TSH receptors, although a small percentage of patients may have none of these antibodies present. A percentage of the inhabitants may also have these antibodies without developing Hashimoto's thyroiditis.

The genes concerned vary in different ethnic groups and the incidence is increased in patients with chromosomal disorders, including Turner, Down's, and Klinefelter's syndromes usually linked with autoantibodies against thyroglobulin and thyroperoxidase. The underlying specifics of the immune system destruction of thyroid cells are not clearly understood. Various autoantibodies may be present against thyroid peroxidase, thyroglobulin and TSH receptors, although a small percentage of patients may have none of these antibodies present. A percentage of the inhabitants may also have these antibodies without developing Hashimoto's thyroiditis. Hypothyroidism caused by Hashimoto's Thyroiditis is treating with thyroid hormone substitute agents such as levothyroxine or desiccated thyroid extract. 

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Multiple Sclerosis

Multiple Sclerosis is a disease, which affects the link between the brain and the spinal cord. Since MS, is an autoimmune disease, the immune system is the main offender to severing the communication between the brain and the spinal cord. Since MS, affect the spinal cord and the brain, the entire nervous system becomes imbalanced. This imbalance produces a buildup of scar tissue, which destroy all of the myelin which covers the anxiety. Human beings depend on myelin to send communication back and forth to the spine and the brain.

Scientists and doctors have attempted to explore for a cause for MS, but unfortunately, all that remains is hypotheses. Either hereditary or an impure environment, links individuals to the MS disease. Individuals who have constricted MS, will experience; weakness, decreased coordination, blurred vision, and even eye pain. There is no vaccination for MS, or even cure in sight, but there are medicines which can reduce the frequent symptoms. The two most famous medicines shorten the attacks of MS and relieve the symptoms of the disease.

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Diabetes

1. Diabetes is metabolism confusion. During consumption, our body breaks mainly of our food down into glucose. It just so happens, that the main source of power and fuel is, glucose. When an individual has diabetes their body does not make enough insulin to be able to move their glucose throughout their body. Therefore, that individual does not accept the necessary fuel and energy.

2. Type 1 Diabetes: This is an autoimmune disease which causes the immune system to fight adjacent to the body. When an individual has diabetes, their immune system attacks the insulin-make beta cells in the pancreas. Due to this, the glucose becomes inactive and cannot survive. In order to survive, an individual with diabetes must take an insulin shot daily.

3. Type 2 Diabetes: Insulin resistance or Type 2 Diabetes is the most common form of diabetes. In the case of Type 2 Diabetes, an individual is producing enough insulin, but for unknown reasons cannot effectively use it. Although, the origin is dissimilar from type 1 diabetes the result is the same; the glucose becomes sedentary, rendering it useless.

4. Gestational Diabetes: Gestational Diabetes can only happen during pregnancy. This disease is strictly based on plasma glucose values deliberate during the OGTT. A woman’s glucose levels must be closely monitored during pregnancy, because their levels usually drop. In the case, of gestational diabetes, but, they almost become nonexistent.

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Lupus

The country has lined up a set of its finest soldiers to protect the land. Although they may have faltered in the past, any enemy they have come across they have occupied. They begin to fire reverse at their own. This is the exact idea behind the autoimmune disease Lupus. Lupus is an autoimmune disease, which forces the body’s natural guard; the immune system, to attack the the internal tissues. When this occurs, it forces internal irritation and swelling of the damaged tissue.

Initially, an individual who suffers from Lupus, will experience inflammation inside. If the Lupus evolves into a harsh form, it can cause problems with the heart, lungs, nervous system, or the blood system. Although the correct cause of Lupus is unknown, scientists do have a wide range of theories. The two most notable theories are that Lupus is triggered by a viral disease or through hereditary lines. When an individual first contracts Lupus, they will experience combined pain, a skin rash, or a fever.

Once the symptoms decline, an individual becomes susceptible to more severe symptoms, such as organ problems. Since Lupus, produces a broad range of symptoms; there are some different remedies. If the individual experiences a skin rash, a doctor will set a corticosteroid cream; in the event of joint pain, and individual will be prescribed non-steroidal anti-inflammatory drugs, and if the person feels an irresistible sense of fatigue, a doctor will take antimalarial medicines.

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